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Record W1973951307 · doi:10.1051/medsci/20031910981

Rôle de la réponse immunitaire innée dans le cerveau

2003· review· fr· W1973951307 on OpenAlex
Véronique Blais, Serge Rivest

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

Venuemédecine/sciences · 2003
Typereview
Languagefr
FieldImmunology and Microbiology
TopicImmune Response and Inflammation
Canadian institutionsUniversité LavalCentre hospitalier de l'Université Laval
Fundersnot available
KeywordsInnate immune systemNeurodegenerationMicrogliaNeuroscienceBiologyInflammationCentral nervous systemImmune systemImmunityNervous systemImmunologyMedicineDiseasePathology

Abstract

fetched live from OpenAlex

There is an innate immune system in the brain. It is inducible in a transient manner from the structures that are devoid of blood brain barrier and thereafter within parenchymal microglia during systemic infection. Transcriptional activation of genes encoding proteins of the innate immunity also takes place in diseases of the central nervous system. This recent discovery raised the hypothesis that inflammation and innate immunity may be involved in the etiology of neurodegenerative disorders. Nevertheless, this system is able to trigger the release of neurotrophic factors and to protect neuronal elements during brain infection and trauma. The innate immune response may play a critical role in protecting neurons and be a possible cause of neurodegeneration. The fate of this newly identified cascade of events is therefore likely to have a determinant impact on the central nervous system during infection and injury.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.006
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Science and technology studies, Research integrity, Insufficient payload (model declined to judge)
Consensus categoriesScience and technology studies, Insufficient payload (model declined to judge)
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.950
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0060.001
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.001
Science and technology studies0.0030.005
Scholarly communication0.0000.000
Open science0.0020.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0020.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.027
GPT teacher head0.308
Teacher spread0.281 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it