Ribosome-Dependent ATPase Interacts with Conserved Membrane Protein in Escherichia coli to Modulate Protein Synthesis and Oxidative Phosphorylation
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Post-publication record
- Nature
- Retraction
- Reason
- Concerns/Issues about Image;Duplication of/in Image;Euphemisms for Duplication;Objections by Author(s);Original Data and/or Images not Provided and/or not Available;Unreliable Results and/or Conclusions;
- Date
- 6/16/2025 0:00
- Flagged by OpenAlex?
- Yes
Source: Retraction Watch, joined by DOI. OpenAlex records retraction as is_retracted, a boolean over a state space with at least four values, so it cannot express an expression of concern, a correction or a reinstatement — it reports them as false, which reads as “fine”.
Abstract
Elongation factor RbbA is required for ATP-dependent deacyl-tRNA release presumably after each peptide bond formation; however, there is no information about the cellular role. Proteomic analysis in Escherichia coli revealed that RbbA reciprocally co-purified with a conserved inner membrane protein of unknown function, YhjD. Both proteins are also physically associated with the 30S ribosome and with members of the lipopolysaccharide transport machinery. Genome-wide genetic screens of rbbA and yhjD deletion mutants revealed aggravating genetic interactions with mutants deficient in the electron transport chain. Cells lacking both rbbA and yhjD exhibited reduced cell division, respiration and global protein synthesis as well as increased sensitivity to antibiotics targeting the ETC and the accuracy of protein synthesis. Our results suggest that RbbA appears to function together with YhjD as part of a regulatory network that impacts bacterial oxidative phosphorylation and translation efficiency.
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The record
- Venue
- PLoS ONE
- Topic
- RNA and protein synthesis mechanisms
- Field
- Biochemistry, Genetics and Molecular Biology
- Canadian institutions
- Carleton UniversityUniversity of Toronto
- Funders
- Canadian Institutes of Health Research
- Keywords
- Oxidative phosphorylationBiologyRibosomeProtein biosynthesisEscherichia coliCell biologyBiochemistryMembrane proteinMutantPhosphorylationTransfer RNATranslation (biology)RNAGeneMessenger RNAMembrane
- Has abstract in OpenAlex
- yes