Note: Transient negative ions as initiators of oxygen fixation in <20 eV electron-irradiated DNA
Bibliographic record
Abstract
This note represents a significant addition to our previous manuscript [N. Mirsaleh-Kohan, A. D. Bass, P. Cloutier, S. Massey, and L. Sanche, J. Chem. Phys. 136, 235104 (2012)] where we demonstrated that enhancements in the electron stimulated desorption yields of O− and OH− from O2 exposed DNA samples were due to the reactions of O2 with electron-induced damage sites within the DNA. Here, we investigate the attachment of O2 to electron-irradiated DNA as a function of electron energy and find a local maximum for O2 attachment to DNA at ∼11.4 eV. This reaction is likely initiated by the production of transient negative ions that dissociate to form RCHx−1• radicals. This work is thus relevant to our understanding of how O2 modulates radiation induced damage in cellular DNA and upon the question of the radio-sensitization of cells during, for example, radiotherapy.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.011 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".