Control At The Cell Center: The Role Of Spindle Poles In Cytoskeletal Organization And Cell Cycle Regulation
Bibliographic record
Abstract
Microtubule organizing centres (MTOCs), which include fungal spindle pole bodies and centrosome in higher eukaryotes, are a structurally diverse group of organelles that share a conserved role in microtubule nucleation and spindle formation. However, recent studies propose that the function of MTOC components extends far beyond these established roles. Numerous cell cycle regulators, checkpoint proteins and microtubule plus tip binding proteins localize to MTOCs during the cell cycle, suggesting that these organelles serve as cellular scaffolds. In addition, several MTOC components such as gamma-tubulin and its associating proteins have been directly implicated in the control of cell cycle progression, activation of checkpoint responses and the regulation of microtubule organization and dynamics. Collectively, these findings implicate MTOCs as cellular control centers that coordinate events at both microtubule minus ends and plus ends with the cell cycle. In this review, we discuss recent studies that support a role for MTOC components, in particular gamma-tubulin, in cell cycle progression, checkpoint response and the coordination of microtubule organization and dynamics.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".