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Record W1975266801 · doi:10.4141/a03-021

Amino acid requirements in inflammatory states

2003· article· en· W1975266801 on OpenAlexvenueno aff
C. Obled

Bibliographic record

VenueCanadian Journal of Animal Science · 2003
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicSulfur Compounds in Biology
Canadian institutionsnot available
Fundersnot available
KeywordsAmino acidGlutamineBiochemistryMetabolismAmino acid synthesisInflammationLimitingBiologyProtein biosynthesisChemistryCell biologyLysineImmunology

Abstract

fetched live from OpenAlex

The metabolic disturbances that accompany an inflammatory challenge redirect nutrients from physiological processes important for growth and reproduction toward processes important in host defense. These processes can require increased provision of particular amino acids from the diet in order to spare body protein stores. The pathways that are activated in response to inflammation have to be determined in order to quantify their specific amino acid requirements. For example, increased synthesis of acute phase proteins would require additional supply of specific amino acids according to their amino acid composition. Some dispensable amino acids can become limiting because their de novo synthesis could be impaired and/or be insufficient to cover the increased demands for synthesis of important metabolites. Moreover, amino acids can act on gene expression and as mediators or signal molecules and modulate numerous functions. However, the optimal conditions, especially concentration in physiological liquids, all owing the best expression of these activities are not yet well defined. Key words: Amino acids, requirements, inflammation, protein, metabolism, glutathione, glutamine

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.249
Threshold uncertainty score0.344

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.018
GPT teacher head0.262
Teacher spread0.244 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations32
Published2003
Admission routes1
Has abstractyes

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