Atmospheric Pressure Deposition of Micropatterned Nitrogen‐Rich Plasma‐Polymer Films for Tissue Engineering
Why this work is in the frame
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Bibliographic record
Abstract
Abstract Summary: A novel atmospheric‐pressure plasma‐polymerised thin film material has been deposited on various substrates using a pilot scale dielectric barrier discharge (DBD) reactor. Deposition kinetics and physico‐chemical characterisation data of nitrogen‐rich plasma‐polymerised ethylene (PPE:N) films, obtained using feed gas mixtures of N 2 (ca. 10 slm) and C 2 H 4 (ca. 10 sccm) are described. Nitrogen concentrations, [N], in the PPE:N films up to ca. 40% were determined by XPS; the concentrations of N‐functionality of greatest interest, primary amines, were determined by chemical derivatisation with 4‐trifluoromethylbenzaldehyde. The PPE:N films were further characterised by attenuated total reflectance infra‐red spectroscopy (ATR‐FTIR), contact angle goniometry, and atomic force microscopy (AFM). Square arrays of PPE:N “islands”, for example 30 μm in diameter repeated every 200 μm, were deposited on polymers, for example biaxially oriented poly(propylene) (BOPP), through specially‐prepared Kapton® polyimide masks. Cell culture experiments were then conducted on these micro‐patterned surfaces, using various cell types of interest in orthopaedics, for example growth plate and articular chondrocytes, or human U937 macrophages, the latter of which do not adhere to existing cell culture dishes. In all these cases the cells rapidly adhered and proliferated on the PPE:N islands, but not elsewhere on the polymer surfaces. In an effort to gain insight into cell adhesion mechanisms, adhesion of both macrophages and chondrocytes was tested against films with different [N] values. U‐937 macrophages adhered to films containing 25% or more [N], but not at all to films with lower values of [N], suggesting the existence of a “critical” value, [N] crit , necessary to induce cell adhesion. Adhesion of U‐937 macrophages on PPE:N‐micropatterned biaxially oriented poly(propylene) substrates. magnified image Adhesion of U‐937 macrophages on PPE:N‐micropatterned biaxially oriented poly(propylene) substrates.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it