Mimetics of the Selenoenzyme Glutathione Peroxidase: Novel Structures and Unusual Catalytic Mechanisms
Bibliographic record
Abstract
Glutathione peroxidase (GPx) mimetics comprise an important class of selenium-containing antioxidants that catalyze the destruction of biologically harmful peroxides in the presence of stoichiometric thiol reductants. The synthesis of two novel cyclic selenium compounds and their evaluation as GPx mimetics was achieved. The first is a cyclic seleninate ester that is formed in situ from the oxidation of allyl 3-hydroxypropyl selenide. The second is a spirodioxyselenurane that is similarly formed from di(3-hydroxypropyl) selenide. Both compounds were shown to be remarkably active catalysts in an assay based on the reduction of t-butyl hydroperoxide with benzyl thiol. The mechanisms of the catalytic cycles of the two novel selenium compounds were elucidated and were found to be distinct from each other and from that of GPx. Keywords: Cyclic seleninate estersglutathione peroxidase mimeticsspirodioxyselenuranes Acknowledgments We thank the Natural Sciences and Engineering Research Council of Canada for financial support.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".