Antioxidant treatment reverses vascular remodeling, but not myogenic tone in mesenteric resistance arteries of stroke-prone spontaneously hypertensive rats (SHRSP)
Bibliographic record
Abstract
Myogenic contraction of resistance arteries contributes significantly to autoregulation of blood flow in vascular beds in hypertension. High blood pressure may be associated with increased oxidative stress, which could induce vascular remodeling and myogenic vasoconstriction. Therefore, we tested the hypothesis that antioxidant treatment with vitamin C or E could prevent the development of structural changes and myogenic responses in resistance arteries of 16 week old SHRSP. After 6 weeks of treatment with vitamin C (1000 mg/d) or vitamin E (1000 IU/d), internal diameter and media thickness in 3rd order mesenteric resistance arteries were measured in an in vitro isobaric vessel preparation. Endothelium-dependent acetylcholine (10−9 to 10−4 mol/L) induced relaxation in mesenteric arteries showed that maximal acetycholine response was increased in vitamin C (80 ± 5%) and vitamin E (70 ± 5%) groups compared to control (37 ± 13%). Lumen diameter of resistance arteries from vitamin E-treated rats was larger (269 ± 26 μm), whereas media thickness (18.1 ± 1.1 μm) and media/lumen ratio were smaller (6.8 ± 0.4%) than in control rats (189 ± 7 μm, 23.3 ± 1.1 μm and 12.4 ± 0.7%, respectively), without change in cross-sectional area. Intraluminal pressure was gradually increased from 20 to 160 mmHg under active and passive (10 mM EGTA) conditions. Myogenic constraction was not different among groups; the normalized diameter (percentage of a given passive lumen diameter) at pressure 80 and 140 mmHg were different by only 2–5% between the 3 groups. In conclusion, antioxidant vitamin treatment corrected vascular remodeling and endothelial function, but did not affect the myogenic response in SHRSP.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".