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Record W1976251743 · doi:10.1021/cr9000226

ABC Efflux Pump-Based Resistance to Chemotherapy Drugs

2009· review· en· W1976251743 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
aboutThe title or abstract carries a Canadian signal from the geographic lexicon.

Bibliographic record

VenueChemical Reviews · 2009
Typereview
Languageen
FieldMedicine
TopicDrug Transport and Resistance Mechanisms
Canadian institutionsUniversity of Guelph
Fundersnot available
KeywordsCitationEffluxComputer scienceSocial mediaLibrary scienceWorld Wide WebInformation retrievalChemistry

Abstract

fetched live from OpenAlex

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTABC Efflux Pump-Based Resistance to Chemotherapy DrugsPaul D. W. Eckford and Frances J. Sharom*View Author Information Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada N1G 2W1* To whom correspondence should be addressed. Tel.: 519-824-4120 ext 52247. Fax: 519-837-1802. E-mail: [email protected]Cite this: Chem. Rev. 2009, 109, 7, 2989–3011Publication Date (Web):May 12, 2009Publication History Received17 January 2009Published online12 May 2009Published inissue 8 July 2009https://pubs.acs.org/doi/10.1021/cr9000226https://doi.org/10.1021/cr9000226review-articleACS PublicationsCopyright © 2009 American Chemical SocietyRequest reuse permissionsArticle Views6912Altmetric-Citations480LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Drug resistance,Membranes,Modulators,Peptides and proteins,Surface interactions Get e-Alerts

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Insufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.923
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0060.002
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0000.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.040
GPT teacher head0.350
Teacher spread0.310 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it