Bibliographic record
Abstract
Epidermolysis bullosa (EB) refers to a group of genodermatoses that present with skin fragility. Patients with this condition present life-long blistering and bullae formation in their skin and mucosal membranes as a response to minor friction or trauma. A revised classification has recently been published and three major types of EB we are identified: simplex, junctional and dystrophic. In each of these subtypes a spectrum of clinical manifestations can be found, varying from very mild to disfiguring and disabling disease. Pediatricians are likely to be the first to encounter patients with EB. Patients may be born with findings suggestive of EB or develop these shortly after. The initial severity of presentation does not indicate prognosis, so clinical classification early on is discouraged. Regardless of the subtype of EB, pediatricians should be aware of the constellation of findings they might encounter when caring for these patients. Although many of the efforts are going to be directed to prevention of skin lesions and wound care, this is not a condition that is limited to the skin. Patients may develop systemic compromise, involving eyes, teeth, oral mucosa, gastrointestinal tract, genitourinary tract and respiratory, cardiovascular, musculoskeletal and hematological systems. In the absence of a cure for EB, efforts are targeted towards prevention and treatment of complications and towards improving patients quality of life. In order to do this, pediatricians should be aware of possible complications, recognize them promptly and provide appropriate care.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.002 | 0.002 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.002 | 0.004 |
| Insufficient payload (model declined to judge) | 0.005 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".