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Record W1976298267 · doi:10.2174/157339608787407672

Epidermolysis Bullosa: The Pediatricians Role

2008· article· en· W1976298267 on OpenAlex
Irene Lara‐Corrales, Elena Pope

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueCurrent Pediatric Reviews · 2008
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicSkin and Cellular Biology Research
Canadian institutionsHospital for Sick ChildrenUniversity of TorontoSickKids Foundation
Fundersnot available
KeywordsMedicineEpidermolysis bullosaJunctional epidermolysis bullosa (veterinary medicine)Genitourinary systemDermatologyDiseaseIntensive care medicinePediatricsInternal medicine

Abstract

fetched live from OpenAlex

Epidermolysis bullosa (EB) refers to a group of genodermatoses that present with skin fragility. Patients with this condition present life-long blistering and bullae formation in their skin and mucosal membranes as a response to minor friction or trauma. A revised classification has recently been published and three major types of EB we are identified: simplex, junctional and dystrophic. In each of these subtypes a spectrum of clinical manifestations can be found, varying from very mild to disfiguring and disabling disease. Pediatricians are likely to be the first to encounter patients with EB. Patients may be born with findings suggestive of EB or develop these shortly after. The initial severity of presentation does not indicate prognosis, so clinical classification early on is discouraged. Regardless of the subtype of EB, pediatricians should be aware of the constellation of findings they might encounter when caring for these patients. Although many of the efforts are going to be directed to prevention of skin lesions and wound care, this is not a condition that is limited to the skin. Patients may develop systemic compromise, involving eyes, teeth, oral mucosa, gastrointestinal tract, genitourinary tract and respiratory, cardiovascular, musculoskeletal and hematological systems. In the absence of a cure for EB, efforts are targeted towards prevention and treatment of complications and towards improving patients quality of life. In order to do this, pediatricians should be aware of possible complications, recognize them promptly and provide appropriate care.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.423
Threshold uncertainty score0.725

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.042
GPT teacher head0.312
Teacher spread0.270 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it