Signal Transduction through Dye-Labeled M-DNA Y-Branched Junctions: Switching Modulated by Chemical Reduction of Anthraquinone
Bibliographic record
Abstract
Metal-DNA (M-DNA) is a complex formed between duplex DNA and divalent metal ions which facilitates electron transfer. In this study, 90 base-pair DNA Y-branched junctions were prepared with the electron donor fluorescein attached to one arm and electron acceptors, rhodamine or anthraquinone, to the other arms. Upon formation of M-DNA, the fluorescence of fluorescein was quenched by the electron acceptors, demonstrating that electron transfer could occur through the junction. As well, the quenching was modulated by chemical reduction of anthraquinone, mimicking a chemical switch. Base-pairing defects at the point of the junction were observed to have only a small impact on the quenching, demonstrating the robust nature of electron transfer in M-DNA. Therefore, M-DNA may have extraordinary potential for the development of nanoelectronic devices.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".