A DNAzyme with Three Protein‐Like Functional Groups: Enhancing Catalytic Efficiency of M <sup>2+</sup> ‐Independent RNA Cleavage
Why this work is in the frame
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Bibliographic record
Abstract
Silence of the small motif: Dz10-66 functions at low monovalent ionic strength and exhibits the highest M2+-independent self-cleavage rate reported to date for any nucleic acid catalyst. Dz10-66 also exhibits a catalytic efficiency similar to that of other known Mg2+-dependent DNAzymes. The “tyranny of the small motif”, whereby certain subsequences dominate selections of increased library size did not prevail in the selection of a new DNAzyme with three protein-like functionalities that catalyses intra- and intermolecular RNA cleavage.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it