Bibliographic record
Abstract
Despite significant advances in understanding the pathogenesis of inflammatory bowel disease (IBD), the etiology remains elusive. A commonly considered hypothesis is that IBD results from an inherited predisposition for an abnormal immune response to an environmental trigger such as an infectious agent. The discovery of the first Crohn's disease (CD) susceptibility gene, NOD2/CARD15, which appears to play a role in the host response to microbial infections, lends further support to this hypothesis.1 Furthermore, an infectious organism could be the initiating factor leading to a chronic inflammatory process (IBD) and eventual development of colonic adenocarcinoma. This would be similar to viral agents causing hepatitis and hepatocellular carcinoma or Helicobacter pylori, leading to chronic gastritis and gastric adenocarcinoma. Favoring a bacterial cause for IBD are the animal models of spontaneous colitis (e.g., interleukin 10 knockout mouse) that do not develop colitis in germ-free environments2 and the therapeutic benefit of antibiotics when used as primary therapy for CD.3
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.005 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".