Pulmonary and systemic response to atmospheric pollution
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Full frame distilled prediction
Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
- Candidate categories
- Insufficient payload (model declined to judge)
- Consensus categories
- none
- Domain
- Candidate signal: noneConsensus signal: none
- Study design
- Candidate signal: Not applicableConsensus signal: none
- Genre
- Candidate signal: ReviewConsensus signal: Review
- Teacher disagreement score
- 0.996
- Threshold uncertainty score
- 0.999
- Validation status
machine_predicted_unvalidated·codex-gemma-dda1882f352a
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.002 |
Machine scores (provisional)
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
- Teacher spread
- 0.304 · how far apart the two teachers sit on this one work
- Validation status
score_only:v0-immature-baseline· verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
Abstract
The inhalation of toxic particles and gases reduces the innate defences of the lung by increasing epithelial permeability, decreasing mucociliary clearance and depressing macrophage function. There is also substantial experimental evidence that lung epithelial cells and alveolar macrophages generate a rich milieu of inflammatory mediators when exposed to atmospheric particles that can be measured in induced sputum, BAL fluid and blood. Here we review evidence that these mediators produce an integrated local lung and systemic inflammatory immune response. That results in an increase in the release of leucocytes and platelets from the bone marrow, an increased production of acute phase proteins from the liver and activation of the vascular endothelium to favour the formation of new and destabilization and rupture of existing atherosclerotic plaques. We postulate that when this response is generated in elderly persons whose lungs are compromised by COPD, it may account for the acute exacerbations of COPD that destroy the quality of life and increase the need for medical attention and hospital admissions. Moreover, the accelerated spread of the atherosclerotic process, and destabilization of existing atherosclerotic plaques in experimental animals that develop atherosclerosis naturally when exposed to atmospheric particles, may account for the acute coronary syndromes, myocardial infarction, transient cerebral ischaemia and stroke that have been documented in humans exposed to episodes of air pollution.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
The record
- Venue
- Respirology
- Topic
- Air Quality and Health Impacts
- Field
- Environmental Science
- Canadian institutions
- St. Paul's HospitalUniversity of British Columbia
- Funders
- not available
- Keywords
- MedicineLungMucociliary clearanceInflammationImmune systemSystemic inflammationInhalationImmunologyPathologyInternal medicineAnesthesia
- Has abstract in OpenAlex
- yes