Bibliographic record
Abstract
LettersOctober 15, 2013Statin Toxicity From Macrolide Antibiotic CoprescriptionSonja Gandhi, BSc and Amit X. Garg, MD, PhDSonja Gandhi, BScFrom Western University, London, Ontario, Canada.Search for more papers by this author and Amit X. Garg, MD, PhDFrom Western University, London, Ontario, Canada.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-159-8-201310150-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We disagree that inclusion of a nondrug comparator group would have been useful, because patients with infection who receive antibiotics would be expected to have a different risk for outcomes than those who do not receive antibiotics (and a comparison of the 2 groups would be heavily criticized for confounding by indication). Rather, we recently published another study to reassure readers that the associations that we reported in all probability reflect differences related to the type of macrolide antibiotic coprescribed with a statin (1).In brief, this second study was also conducted using large health care databases in ...Reference1. Fleet JL, Shariff SZ, Bailey DG, Gandhi S, Juurlink DN, Nash DM, et al. Comparing two types of macrolide antibiotics for the purpose of assessing population-based drug interactions. BMJ Open. 2013;3:. [PMID: 23847265] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Western University, London, Ontario, Canada.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M12-1300. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoStatin Toxicity From Macrolide Antibiotic Coprescription Amit M. Patel , Salimah Shariff , David G. Bailey , David N. Juurlink , Sonja Gandhi , Muhammad Mamdani , Tara Gomes , Jamie Fleet , Y. Joseph Hwang , and Amit X. Garg Statin Toxicity From Macrolide Antibiotic Coprescription Houman Farzin , Mai Takematsu , and Robert S. Hoffman Metrics October 15, 2013Volume 159, Issue 8Page: 575KeywordsAcute renal failureAdverse eventsAntibioticsDatabasesDrug administrationDrug interactionsDrugsErythromycinFoodHospitalizationsInformation storage and retrievalPharmacokineticsPhysiciansResearch laboratoriesRespiratory infectionsRhabdomyolysisStatinsToxicityUpper respiratory tract infections ePublished: 15 October 2013 Issue Published: October 15, 2013 CopyrightCopyright © 2013 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.026 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.025 | 0.005 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".