Immune response of adults with secondary immunodeficiency to pediatric Haemophilus influenzae type b (Hib) vaccine
Bibliographic record
Abstract
Patients with chronic renal failure (CRF) develop secondary immunodeficiency as a result of the uremic state and its metabolic consequences, along with a negative impact of the dialysis procedure on the immune system. Such patients are therefore at high risk for septicemia and other severe infections. In non-vaccinated adults, protection against Haemophilus influenzae type b (Hib) is mediated by natural anti-capsular polysaccharide antibody. We hypothesized that non-vaccinated adults with CRF lack protective antibody against Hib, but may respond to the pediatric Hib vaccine. Serum anti-Hib IgG and IgM were studied in 60 patients with CRF and 40 healthy controls. Thirty-two patients and 19 controls were immunized with one dose of pediatric Hib vaccine; serum antibody levels were assessed pre- and 1, 6, 9 months post-vaccine. Functional antibody activity was studied using a serum bactericidal assay. Almost 90% of controls, but only 43% of non-vaccinated CRF patients had protective anti-Hib antibody. Four week post-vaccination, all but one patient (97%) have developed protective antibody with a 14-fold increase (P<0.05); in 29 out of 32 (91%) the antibody exhibited bactericidal activity. In the majority of patients, protective antibody persisted 9 months post-vaccine. The vaccine response did not depend on the age, but was lower in CRF patients who had type 2 diabetes, COPD, or heart disease, compared to the rest of the group. Most adult patients with CRF are at an increased risk of acquiring invasive Hib disease as they lack protective antibody. The pediatric Hib vaccine is highly immunogenic in this group, with higher response compared to other vaccines administered to such patients (hepatitis B and pneumococcal vaccines). This study provides rationale for the immunization of individuals with secondary immnunodeficiency against Hib to achieve protective immunity.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".