Bibliographic record
Abstract
The recent completion of five trials comparing the strategy of rhythm control versus the strategy of rate control in the management of recurrent atrial fibrillation has advanced considerably our understanding of the treatment of this common clinical problem. The background to this research question is outlined, followed by an overview of the five trials and their results. Data on important clinical events from four of the trials are pooled and presented. The aggregate results of the trials do not demonstrate any clear advantage of the rhythm control approach. The findings elevate rate control to the position of an acceptable primary therapy in the types of patients studied and underline the concept that the primary goal of antiarrhythmic therapy for atrial fibrillation at this time is control of symptoms. Under these circumstances, a "safety first" approach is prudent and monitoring for adverse drug effects is mandatory. The results underscore the importance of continuous anticoagulation in patients with stroke risk factors. Finally, the results from these trials help to set the agenda for future research on rhythm management in atrial fibrillation.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.007 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.011 | 0.017 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".