Central Pulsatile Hemodynamic Effects of Acute Peak Treadmill Exercise during Pregnancy
Bibliographic record
Abstract
Hemodynamic adaptation, during normal human pregnancy, involves interrelated alterations in heart rate, arterial compliance, blood pressure and aortic and left ventricular structure and function. Advances in our understanding of pulsatile hemodynamics are important for defining, preventing and treating the pathophysiological states associated with the arterial wall, not only in the non-pregnant population but also in pregnancy (e.g., hypertension, preeclampsia). Despite evidence of cardiovascular benefits from aerobic exercise in the non-pregnant population, no study has investigated the effects of exercise during pregnancy on pulsatile hemodynamics. PURPOSE: To investigate the pulsatile hemodynamics in active pregnant women before and after an acute bout of peak exercise. METHODS: Using calibrated tonometry of the brachial, radial, femoral and carotid arteries, pre- and post-exercise hemodynamic measures were performed in 8 pregnant women at 16–20 weeks gestation and 11 non-pregnant women in the luteal phase. The exercise protocol consisted of a single bout of peak treadmill exercise using a modified Balke protocol. RESULTS: At baseline, the pregnant group had a higher forward pressure wave amplitude (44.5 ± 2.2 (SE) vs. 37.5 ± 2.3 mmHg.; p <0.05) and lower augmentation index (−20.6 ± 3.7 vs. 0.9 ± 3 %; p <0.001). Resting heart rate was higher in the pregnant women (91 ± 6 vs. 77 ± 3 bpm; p <0.05) with no differences between groups in VO2, VCO2, VE and RER. Peak work rate and time to peak were not different. Heart rate, VO2, VCO2, VE and RER were not different at peak exercise and post-exercise. Following peak exercise, the forward pressure wave fell dramatically in the pregnant group (44.5 ± 2.2 vs. 30.3 ± 2.2 mmHg; p <0.05) and remained unchanged in the non-pregnant women. CONCLUSION: Since cardiac output and stroke volume presumably increased with exercise, our findings are indicative of augmented short-term dynamic matching between aortic flow and impedance in healthy pregnant women. The reduction in forward pressure wave amplitude in the setting of increased cardiac output suggests that modulation of aortic characteristic impedance, a major determinant of forward wave amplitude, may be involved in the acute adaptation to exercise in pregnancy.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".