Involvement of Serotonergic Mechanisms in the Disruption of Ovine Duodenal Migrating Myoelectric Complex Cycles by Duodenal Acidification
Bibliographic record
Abstract
Infusions of 1 and 4 mmol of HCl (pH 2.0) into the duodenal bulb of conscious sheep, within 30% of the period of the migrating myoelectric complex (MMC) cycle, induced aborally propagated premature phases of regular spiking activity (RSA) on the proximal duodenum. A transient inhibition of reticular contractions and a shortening of the period of subsequent duodenal MMC cycles were obtained with infusions of 4 mmol of HCl but not with infusions of 1 mmol. When the animals were pretreated with the 5-hydrotryptamine (5-HT) antagonists, ritanserin (0.2 mg/kg) and metergoline (0.5 mg/kg), 15 min before duodenal infusions of 4 mmol of HCl, premature RSAs and inhibition of reticular contractions were still elicited, but shortening of the subsequent duodenal MMC cycles did not occur. It is concluded that the shortening of duodenal MMC cycles induced by duodenal infusions of 4 mmol of HCl involved a serotonergic mechanism incorporating 5-HT2 receptors. The premature duodenal RSA and inhibition of reticular motility also elicited by these infusions appeared to be independent of this serotonergic system.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".