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Record W1980609384 · doi:10.1021/ja900256g

Synthesis and Reactivity of Phosphine-Stabilized Phosphoranimine Cations, [R<sub>3</sub>P·PR′<sub>2</sub>═NSiMe<sub>3</sub>]<sup>+</sup>

2009· article· en· W1980609384 on OpenAlexaff
Keith Huynh, Alan J. Lough, Michelle A. M. Forgeron, M. Bendle, Alejandro Presa Soto, Roderick E. Wasylishen, Ian Manners

Bibliographic record

VenueJournal of the American Chemical Society · 2009
Typearticle
Languageen
FieldChemistry
TopicOrganometallic Complex Synthesis and Catalysis
Canadian institutionsUniversity of TorontoUniversity of Alberta
Fundersnot available
KeywordsChemistryDiphosphinesPhosphineMedicinal chemistryLigand (biochemistry)BromideReactivity (psychology)CatalysisOrganic chemistry

Abstract

fetched live from OpenAlex

A series of phosphine-stabilized phosphoranimine cations [R(3)P x PR'(2)=NSiMe(3)](+), which can be regarded as derivatives of the proposed transient reactive intermediate [PR'(2)=NSiMe(3)](+) in the thermal condensation polymerization of phosphoranimines (R''O)PR'(2)=NSiMe(3) to form poly(alkyl/arylphosphazenes) [PR'(2)=N](n) at 180-200 degrees C, have been prepared. The bromide salts [R(3)P x PR'(2)=NSiMe(3)]Br [R' = Me ([6](+)), OCH(2)CF(3) ([8](+)); R(3)P = Me(3)P (a), Et(3)P (b), (n)Bu(3)P (c), dmpm (d, dmpm = dimethylphosphinomethane), dmpe (e, dmpe = dimethylphosphinoethane)] were prepared from the direct reactions between BrMe(2)P=NSiMe(3) (5) and Br(CF(3)CH(2)O)(2)P=NSiMe(3) (7) and the corresponding tertiary phosphines R(3)P or the diphosphines Me(2)P(CH(2))(n)PMe(2) (n = 1, 2). Cations of the type [6](+) and [8](+), with electron-donating and -withdrawing groups at the phosphoranimine phosphorus center, respectively, undergo facile phosphine ligand substitution with the strong N-donor 4-dimethylaminopyridine (DMAP) to yield the corresponding DMAP-stabilized salts [DMAP x PR(2)=NSiMe(3)]Br [R = Me ([9](+)), OCH(2)CF(3) ([10](+))]. Cations [6](+) with Br(-) anions are particularly labile: for example, [6a]Br slowly releases PMe(3), BrSiMe(3), and forms cyclic phosphazenes such as [Me(2)P=N](4). Anion exchange reactions between the salts [6b]Br or [8c]Br and AgOTf (OTf = CF(3)SO(3)) quantitatively afforded the corresponding and more stable triflate salts [6b]OTf and [8c]OTf. Phosphine ligand abstraction reactions with B(C(6)F(5))(3) were observed for the bromide salts [6b]Br and [8c]Br, which regenerated the phosphoranimines 5 and 7, respectively, and formed the adduct R(3)P x B(C(6)F(5))(3). In contrast, the triflate salts [6b]OTf and [8c]OTf were unreactive under the same conditions. X-ray structural analysis of the P-donor stabilized cations revealed longer P-P and P-N bond lengths and smaller P-N-Si bond angles for cations [6](+) compared to analogs [8](+). These structural differences were rationalized using the negative hyperconjugation bonding model. In addition, the (1)J(PP) coupling constants for the cations [6](+) observed by both solution and solid-state (31)P NMR are remarkably small (13-25 Hz), whereas those for [8](+) are substantially larger and positive (276-324 Hz) and are as expected for P(IV)(+)-P(V) systems. DFT studies suggest that the significant difference in (1)J(PP) couplings observed for [6](+) and [8](+) appears to be related to the electronegativity of the R' substituents at the phosphoranimine phosphorus center rather than the strength of the donor-acceptor P-P bond, which is slightly weaker in [6](+) relative to that in [8](+), as indicated by the X-ray data and reactivity studies.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.084
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0020.002
Bibliometrics0.0000.001
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.008
GPT teacher head0.217
Teacher spread0.209 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations17
Published2009
Admission routes1
Has abstractyes

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