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Record W1980725116 · doi:10.1038/ng.764

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

2011· review· en· W1980725116 on OpenAlexaff
Carl A. Anderson, Gabrielle Boucher, Charlie W. Lees, André Franke, Mauro D’Amato, Kent D. Taylor, James Lee, Philippe Goyette, Marcin Imieliński, Anna Latiano, Caroline Lagacé, Regan Scott, Leila Amininejad, Suzannah Bumpstead, Leonard Baidoo, Robert N. Baldassano, Murray L. Barclay, Theodore M. Bayless, Stephan Brand, Carsten Büning, Jean‐Frédéric Colombel, Lee A. Denson, Martine De Vos, Marla C. Dubinsky, Cathryn Edwards, David Ellinghaus, Rudolf S.N. Fehrmann, James Floyd, Timothy H. Florin, Denis Franchimont, Lude Franke, Michel Georges, Jürgen Glas, Nicole L. Glazer, Stephen L. Guthery, Talin Haritunians, Nicholas K. Hayward, Jean‐Pierre Hugot, Gilles Jobin, Debby Laukens, Ian C. Lawrance, Marc Lémann, Arie Levine, Cécile Libioulle, Édouard Louis, Dermot McGovern, Mónica Milla, Grant W. Montgomery, Katherine I. Morley, Craig Mowat, Aylwin Ng, William G. Newman, Roel A. Ophoff, Laura Papi, Orazio Palmieri, Laurent Peyrin‐Biroulet, Julián Panés, Anne Phillips, Natalie J. Prescott, Deborah D. Proctor, Rebecca Roberts, Richard K. Russell, Paul Rutgeerts, Jeremy Sanderson, Miquel Sans, L. Philip Schumm, Frank Seibold, Yashoda Sharma, Lisa A. Simms, Mark Seielstad, A. Hillary Steinhart, Stephan R. Targan, Leonard H. van den Berg, Morten Vatn, Hein W. Verspaget, Thomas D. Walters, Cisca Wijmenga, David C. Wilson, Harm-Jan Westra, Ramnik J. Xavier, Zhen Zhao, Cyriel Y. Ponsioen, Vibeke Andersen, Leif Törkvist, Maria Gazouli, Nicholas P. Anagnou, Tom H. Karlsen, Limas Kupčinskas, Jurgita Šventoraitytė, John Mansfield, Subra Kugathasan, Mark S. Silverberg, Jonas Halfvarson, Jerome I. Rotter, Christopher G. Mathew, Anne M. Griffiths, Richard B. Gearry, Tariq Ahmad, Steven R. Brant, Mathias Chamaillard, Jack Satsangi, Judy H. Cho, Stefan Schreiber, Mark J. Daly, Jeffrey C. Barrett, Miles Parkes, Vito Annese, Håkon Håkonarson, Graham Radford‐Smith, Richard H. Duerr, Séverine Vermeire, Rinse K. Weersma, John D. Rioux

Bibliographic record

VenueNature Genetics · 2011
Typereview
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicInflammatory Bowel Disease
Canadian institutionsHospital for Sick ChildrenMount Sinai HospitalSickKids FoundationUniversity of TorontoHôpital Maisonneuve-RosemontUniversité de MontréalMontreal Heart Institute
FundersNational Institute of Diabetes and Digestive and Kidney DiseasesElse Kröner-Fresenius-StiftungShireNational Heart, Lung, and Blood InstituteExzellenzclusters EntzündungsforschungNational Institutes of HealthSvenska LäkaresällskapetAdessium FoundationKarolinska InstitutetFonds Wetenschappelijk OnderzoekCrohn's and Colitis UKFonds De La Recherche Scientifique - FNRSCedars-Sinai Medical CenterDeutsche ForschungsgemeinschaftNational Center for Research ResourcesNational Institute of Allergy and Infectious DiseasesNational Center for Advancing Translational SciencesLeona M. and Harry B. Helmsley Charitable TrustMedical Research CouncilSwedish Cancer FoundationNederlandse Organisatie voor Wetenschappelijk OnderzoekALS AssociationWellcome TrustNational Institute for Health and Care ResearchAbbott LaboratoriesNational Health and Medical Research Council
KeywordsBiologyUlcerative colitisGeneticsMeta-analysisComputational biologyInternal medicineDisease

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.004
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Meta-analysis · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.004
Threshold uncertainty score0.013

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.004
Meta-epidemiology (narrow)0.0020.000
Meta-epidemiology (broad)0.0040.003
Bibliometrics0.0010.002
Science and technology studies0.0000.000
Scholarly communication0.0010.000
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0040.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.036
GPT teacher head0.330
Teacher spread0.294 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designMeta-analysis
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1,353
Published2011
Admission routes1
Has abstractno

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