Sugar-Substituted Poly(<i>p</i>-phenyleneethynylene)s: Sensitivity Enhancement toward Lectins and Bacteria
Bibliographic record
Abstract
The synthesis of two novel, water-soluble, sugar-substituted poly( p -phenyleneethynylene)s and their interactions with concanavalin A (Con A) and bacteria ( Escherichia coli ) are reported, and the issue of sensitivity enhancement is investigated. Both sugar-substituted PPEs ( P5 and P7 ) exhibited strong interactions with Con A with K SV values exceeding 10 8 M −1 . The binding constants between the sugar-substituted polymers and Con A were also quantitatively calculated using isothermal titration calorimetry (ITC) resulting in association constants as high as 10 6 M −1 . P5 and P7 strongly interact with mannose-binding E. coli, which led to their aggregation.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".