RENAL ISCHEMIA/REPERFUSION INJURY PREVENTED BY A NOVEL INDUCIBLE NITRIC OXIDE SYNTHASE INHIBITOR, fr260330, IN NONHUMAN PRIMATES
Bibliographic record
Abstract
P55 Background: Ischemia/reperfusion (I/R) injury can be involved in almost all tissues and organs during pathosis. Over the past decade, an enormous number of studies have focused on the role of nitric oxide (NO). Cytotoxic nitric oxide (NO) is produced during ischemia/reperfusion (I/R) injury by expression of inducible NO synthase (iNOS). Therefore, continuous iNOS inhibition might prevent early graft dysfunction. FR260330 is a potent and selective inhibitor of iNOS activity by preventing iNOS monomers from dimerization. In this study, the effect of FR260330 in prevention of renal I/R injury was evaluated in the model of one kidney ischemia in Vervet monkeys. Methods. A total of 18 male Vervet monkey were randomly assigned to two groups (n=9). Transient (60 min) left renal ischemia was produced with simultaneous contralateral nephrectomy in FR260330 20 mg/kg/day treated and control groups. Renal function and other biochemistry determinations, and FR260330 concentrations were tested until day 15 after I/R injury. Results: All the monkeys were survival after 60 min I/R injury until sacrifice on day 15 at study termination. Serum creatinine in untreated group increased significantly to compare with FR260330 treated group on day 2, 3, 4, and 7 (p<0.05). Plasma concentration of FR260330 after oral administration showed that Cmas is 3.251 ± 2.526 μg/ml, and Tmax is 4 hrs. Conclusion: A selective inhibitor of nitric oxide synthase, FR260330 effectively prevents renal I/R injury in Vervet monkeys. Potential applications of FR260330 in prevention of delayed graft function patients and other I/R injury pathosis are thus suggested.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".