Antenatal Treatment with Corticosteroids Affects mRNA Expression of Dopamine D1 and D2 Receptors in the Striatum of Developing Rabbit
Bibliographic record
Abstract
The expression levels of dopamine D1 and D2 receptor mRNA have been investigated using Northern blot analysis in developing rabbit striatum after antenatal exposure to betamethasone. Pregnant rabbits were given either 0.1 mg/kg betamethasone or 0.1 mg/kg saline doses twice within 24 h. Dopamine D1 receptor mRNA levels were found significantly higher in the fetuses exposed to antenatal betamethasone than in the saline-treated controls. After birth, dopamine D1 and D2 receptor mRNA levels were both significantly lower in 1- and 25-day-old treated pups but recovered to normal levels in adulthood. These data suggest that antenatal exposure to betamethasone can lead to lasting abnormalities.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".