P2.01 LONGITUDINAL STUDY OF VASCULAR MARKERS OF PREMATURE ATHEROSCLEROSIS IN PEDIATRIC SYSTEMIC LUPUS ERYTHEMATOSUS
Bibliographic record
Abstract
Background Patients with pediatric Systemic Lupus Erythematosus (pSLE) are at increased risk of premature atherosclerosis irrespective of exposure to traditional cardiovascular risk factors. The goals of this study were to determine the progression of vascular markers of premature atherosclerosis in a prospectively followed pSLE cohort and the role of treatment and disease activity related factors. Methods At baseline and first follow-up drug therapy and disease activity were recorded, fasting lipid and glycemic profiles performed; and vascular markers including intima-media thickness (CIMT), flow-mediated dilatation (FMD), and pulse wave velocity (PWV) assessed. Differences between baseline and follow-up time points were tested as paired measures adjusted for time and compared in univariate analysis. Results Forty-three pSLE were assessed at baseline (age 14.0±2.8 years; disease duration 2.3±2.8 years, 81% female) and follow-up (1.6±0.5 years later). No overall difference was observed in CIMT (0.01±0.05 mm, p=0.15), FMD (0.19±5.0 %, p=0.81) and PWV (0.15±1.0 m/sec, p=0.39). When considering the time-dependent effects of treatment and disease activity on these vascular markers, corticosteroid use was found to be negatively associated with CIMT at follow-up (r=−0.44, p=0.004) and remained significant in a multiple variable model (R2=0.63, p<0.001). Conclusion In pSLE of relatively short duration, progression of vascular markers of premature atherosclerosis was not observed over short-term follow-up, but change in CIMT was found to be negatively associated with the amount of corticosteroid use. This suggests aggressive immunotherapy may reduce the atherogenic burden of chronic inflammation in pSLE and warrants further investigation.
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How this classification was reachedexpand
Direct model labels (unvalidated)
Per-model category and study-design labels from the labeling rounds. They are machine output, unvalidated, and the disagreement between models ships as data. No study design here is MEDLINE-validated yet.
| Model arm | Categories | Study design | Confidence |
|---|---|---|---|
| gemma | no category Domain: not available · Genre: Empirical About the Canadian research system: no · About a Canadian topic: no | Observational | low |
| gpt | no category Domain: not available · Genre: Empirical About the Canadian research system: no · About a Canadian topic: no | Observational | high |
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.002 | 0.003 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedLabeled directly by 2 models reading the full record.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".