Expression and regulation of mouse <i>Mtsh1</i> during limb and branchial arch development
Bibliographic record
Abstract
The mouse genome contains at least two genes, Mtsh1 and Mtsh2, related in sequence to the Drosophila homeotic gene teashirt (tsh). In this paper, we report the characterization of Mtsh1 expression in the developing branchial arches and forelimbs during mouse embryogenesis. Mtsh1 was found predominantly transcribed in the mesenchymal tissue of branchial arches and forelimbs. Surgical removal of the epithelium of both forelimb and branchial arch significantly decreased the expression of Mtsh1 in the mesenchymal cells of these tissues. Upon implantation of FGF8-soaked beads into arches and limbs, Mtsh1 transcription was up-regulated. In contrast, when BMP4-soaked beads were implanted, Mtsh1 expression was inhibited. Together, these results suggest that mouse Mtsh1 gene may be involved in the outgrowth of limbs and arches and may be functioning downstream of BMP and FGF signaling pathways.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".