Characteristics of Graves’ Disease in a Cohort of Chronic Hepatitis C Patients Treated With Interferon-alpha and Ribavirin
Bibliographic record
Abstract
Background : Thyrotoxicosis resembling Graves’ disease (GD) in association with interferon- alpha therapy in the treatment of chronic hepatitis C is very uncommon, especially after treatment has ceased. Furthermore, it is unknown if this condition behaves differently from GD arising de novo. Methods : A retrospective analysis was performed to detect and review all cases of GD occurring in our hepatitis C service unit over a five year period including long term outcomes. Results : There were five cases of GD detected: 3 females and 2 males. These were: 1 case of co-existing GD and a toxic nodule developed during therapy, 2 cases developed GD after therapy and another 2 as part of the tri-phasic thyroiditis. All 5 patients were treated for 6 months with one exception and then followed up for another 12 months. Conclusions : All patients responded satisfactorily to short term thionamides and remained in long term remission. Although the number is small, this report is a reminder that more cases can be expected as treatment for chronic HCV is likely to increase. doi:10.4021/jem10w
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".