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The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition

2007· review· en· 1,104 citations· W1983833034 on OpenAlex· 10.1038/sj.onc.1210414

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian affiliationAn author listed a Canadian institution. This is the only route the usual frame has.

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.042
GPT teacher head0.324
Teacher spread
0.282 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

No abstract. This is not a gap in this database — OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

The record

Venue
Oncogene
Topic
Melanoma and MAPK Pathways
Field
Biochemistry, Genetics and Molecular Biology
Canadian institutions
Institute for Research in Immunology and Cancer
Funders
Keywords
BiologyCell biologyCell cycleMAPK/ERK pathwayKinaseProtein kinase ACyclin-dependent kinase 2Mitogen-activated protein kinaseSignal transductionCyclinCyclin-dependent kinase 4Anti-apoptotic Ras signalling cascadeASK1Cell growthMitogen-Activated Protein Kinase 3Mitogen-activated protein kinase kinaseCellBiochemistry
Has abstract in OpenAlex
no