Advances in oral anticoagulants: focus on dabigatran etexilate
Bibliographic record
Abstract
Vitamin K antagonists, predominantly warfarin, have been the cornerstone of anticoagulation therapy for many decades. However, warfarin use is associated with limitations such as a slow onset of action, a narrow therapeutic index, numerous drug interactions, and frequent monitoring is required of prothrombin time and the international normalized ratio. These shortcomings prompted the development of new oral anticoagulants. Dabigatran etexilate is a novel, oral, reversible, direct thrombin inhibitor that acts on the terminal steps of the coagulation cascade overcoming many of warfarin's limitations. Currently, dabigatran etexilate is approved in multiple regions including Europe and Canada, for the primary prevention of venous thromboembolism in adults who have undergone total hip replacement or total knee replacement surgery. A Phase III trial demonstrated noninferiority of dabigatran etexlitate compared with warfarin for the prevention of stroke in patients with atrial fibrillation, and one Phase III trial showed superiority. There are several ongoing trials investigating the acute treatment of venous thromboembolism.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".