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Record W1983905815 · doi:10.1159/000198104

Experimental Production of Diffuse Colitis in Rats

2009· article· en· W1983905815 on OpenAlexaff
Brian MacPherson, C.J. Pfeiffer

Bibliographic record

VenueDigestion · 2009
Typearticle
Languageen
FieldMedicine
TopicMicroscopic Colitis
Canadian institutionsMemorial University of Newfoundland
Fundersnot available
KeywordsColitisMucusCryptRectumDistal colonMedicinePathologyGastroenterologyInternal medicineBiology

Abstract

fetched live from OpenAlex

Diffuse, topical application of dilute acetic acid to the serosal surface of rat colon, or standardized intraluminal (per rectum) instillation induced a reproducible, diffuse colitis in a dose-response manner. These lesions were reproduced with 100% reliability and were evaluated up to 60 days when healing occurred. Histopathological features of this chemically induced colitis were diffuse ulceration of the distal colon, occurrence of pseudopolyp-like structures, alterations in crypt depth and mucus secretion, and a transmural, nonspecific inflammatory response.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.006
Threshold uncertainty score0.020

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0030.001
Meta-epidemiology (broad)0.0020.001
Bibliometrics0.0030.001
Science and technology studies0.0010.001
Scholarly communication0.0010.001
Open science0.0010.002
Research integrity0.0020.004
Insufficient payload (model declined to judge)0.0060.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.014
GPT teacher head0.292
Teacher spread0.278 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations343
Published2009
Admission routes1
Has abstractyes

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