A miniaturized system for imaging vascular response to deep brain stimulation
Bibliographic record
Abstract
We present a miniaturized system for spectroscopic imaging of the cerebrovascular response to deep brain stimulation (DBS). The system consists of an optical module with controllable light emitting diode (LED) illumination and focusing optics, and an electronic module with a high-sensitivity complementary metal oxide semiconductor (CMOS) image sensor, an off-chip controller and a microSD card for image storage. The system is a refinement of our previously described integrated imaging microscope (IIM). Key differences include a further reduced footprint with the head-stage occupying less than 1.5 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> and weighing under 1.5 gm, pulse width modulation (PWM) control of illumination intensity and improved signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) performance. Electrical and optical characterization and simulation data, and experimental data from an anesthetized rat are presented. Combined with integrated instrumentation for electrical stimulation and electrophysiology, we expect the tether-free, animal mountable system to facilitate understanding the long-term vascular and electrical effects of deep brain stimulation in freely-moving animals.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".