Effect of Release of Endogenous Gastrin on Myoelectrical and Mechanical Activity of Isolated Canine Stomach
Bibliographic record
Abstract
The myoelectrical and mechanical activities of the totally isolated, canine stomachs were recorded using five sets of bipolar silver-wire electrodes and one strain gauge. Stomachs were perfused extracorporeally with the blood of living supporting dogs which served as oxygenators and dialysers. Each supporting dog had a permanent antral pouch, accessible for the purpose of irrigation. To suppress the release of endogenous gastrin, this antral pouch and the antrum of the ex vivo stomach were irrigated with acid (pH 3). To induce the release of gastrin, one or both antra were irrigated with 0.2-percent acetylcholine or with 1 M glycine. To compare the action of endogenous gastrin with exogenous gastrin-like peptide, pentagastrin was infused into the gastric artery in doses of 4 mug/h and 8 mug/h. Control recordings were done during the acid irrigation. Endogenous gastrin released from antra by acetylcholine or glycine caused identical changes in the recordings as exogenous pentagastrin. There was a marked increase in the frequency of electrical control activity and of gastric contractions recorded as increased mechanical response. The results indicate that the ex vivo stomach can be used for study of the effect of endogenous gastrin musculature activity under the experimental conditions described.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".