Evidence for an Indirect Component of the Action of Histamine on Canine Portal Vein
Bibliographic record
Abstract
Histamine caused contraction of spiral strips of the canine portal vein. This is an H1 response and no evidence of any H2 receptor activity was observed. The response to histamine was blocked by the alpha-adrenoceptor antagonists phentolamine and prazosin, but not by the alpha 2-receptor blocker yohimbine. Pretreatment of the tissue with 6-hydroxydopamine significantly reduced the response to histamine and tyramine while the response to noradrenaline was unchanged. A marked tachyphylaxis developed to tyramine and histamine, but not to noradrenaline. We conclude that a component of the contractile activity of histamine on the canine portal vein involves release of endogenous catecholamines and that this response is mediated by H1 receptors.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".