Function of Cytosolic Chaperones in Tom70-Mediated Mitochondrial Import
Bibliographic record
Abstract
The great majority of mitochondrial proteins are synthesized by cytosolic ribosomes and then imported into the organelle post-translationally. The translocase of the outer membrane (TOM) is a proteinaceous machinery that contains surface receptors for preprotein recognition and also serves as the main entry gateway into mitochondria. Mitochondrial targeting requires various cytosolic factors, in particular the molecular chaperones Hsc70/Hsp70 and Hsp90. The chaperone activity of Hsc70/Hsp70 and Hsp90 occurs in coordinated cycles of ATP hydrolysis and substrate binding, and is regulated by a number of co-chaperone proteins. The import receptor Tom70 is a member of the tetratricopeptide repeat (TPR) co-chaperone family and contains a conserved TPR clamp domain for interaction with Hsc70 and Hsp90. Such interaction is essential for the initiation of the import process. This review will discuss the roles of Hsc70 and Hsp90 in mitochondrial import and summarize recent progress in understanding these pathways. Keywords: Mitochondria, import, chaperone, Tom70, Hsc70, Hsp90, TOM, ATP hydrolysis, TPR, OM, IM, ATP, Saccharomyces cerevisiae, DNA, GIP, TIM, cytosolic, hydrophobic, hexokinases, DnaK, DnaJ, HPD, DNAJA4, NEF, DNA gyrase B, homodimer, OTC, pmAAT, ANT, AAC, PiC, GA, NB, CiC, OGC, TSPO, Tom71, FKBP38, Cdc37Mitochondria, import, chaperone, Tom70, Hsc70, Hsp90, TOM, ATP hydrolysis, TPR, OM, IM, ATP, Saccharomyces cerevisiae, DNA, GIP, TIM, cytosolic, hydrophobic, hexokinases, DnaK, DnaJ, HPD, DNAJA4, NEF, DNA gyrase B, homodimer, OTC, pmAAT, ANT, AAC, PiC, GA, NB, CiC, OGC, TSPO, Tom71, FKBP38, Cdc37
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".