PCB CONGENERS ASSOCIATED WITH INCREASED RISK OF METABOLIC SYNDROM IN ARCTIC WOMEN
Bibliographic record
Abstract
ISEE-352 Introduction: Human exposure to pollution in the Arctic is a potential health risk for the local populations. Epidemiological studies in Greenland have shown that human blood levels of several organic contaminants are very high, mainly in North and North East Greenland where people depend on local food. In Ittoqqortoormi-it (Scoresbysund) the population has the highest blood levels of several organic pollutants found in Arctic countries, especially PCB which exceed Canadian guideline levels. Thus, these populations may be at increased risk for any potential adverse effect of long term exposure to organic pollutants. Methods: The cross-sectional study which was part of the Arctic Monitoring and Assess Programme included 187 men and168 women (18-49 years) from 4 districts in Greenland. It was based upon questionnaires including dietary survey, anthropometric measures, blood lipids analysis, and determination of heavy metals and organic pollutants (betaHCH, chlordanes, DDTs, hexachlorobenzene, Mirex, PCBs, and toxaphenes). Results: Compared to earlier epidemiological studies in Greenland, we found an increasing proportion of overweight subjects and increased levels of serum triglyceride, cholesterol and cardiovascular risk indices. In addition, both PCBs and DDTs were found to be associated with elevated levels of s-triglyceride and lower HDL. However, the n–3 fatty acids were still associated with the well known lowering effect on serum- triglycerides. Among women only, and after adjustment for age, BMI, n–3/n–6, DDE and DDT, several PCB congeners (CB 99,101,105,128,183) were found to be significantly correlated with increased levels of triglycerides and decreased levels of HDL. Whereas CB 138, 153, 156, 170 and 180 were found to be neutral. Conclusion: It thus seems that for women long time exposure to specific PCB-congeners in the Arctic diet increases risk for metabolic syndrome, despite the protective effect of the dietary fatty acids.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.005 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".