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Record W1985742486 · doi:10.1038/ng.666

Common variants at 19p13 are associated with susceptibility to ovarian cancer

2010· article· en· W1985742486 on OpenAlexaff
Kelly L. Bolton, Jonathan P. Tyrer, Honglin Song, Susan J. Ramus, Maria Notaridou, Chris Jones, Tanya Sher, Aleksandra Gentry‐Maharaj, Eva Wozniak, Ya-Yu Tsai, Joanne B. Weidhaas, Daniel Y. Paik, David J. Van Den Berg, Daniel O. Stram, Celeste Leigh Pearce, Anna H. Wu, Wendy R. Brewster, Hoda Anton‐Culver, Argyrios Ziogas, Steven A. Narod, Douglas A. Levine, Stanley B. Kaye, Robert Brown, James M. Flanagan, Weiva Sieh, Valerie McGuire, Alice S. Whittemore, Ian Campbell, Martin Gore, Jolanta Lissowska, Hanna Yang, Krzysztof Mędrek, Jacek Gronwald, Jan Lubiński, Anna Jakubowska, Nhu D. Le, Linda S. Cook, Linda E. Kelemen, Angela Brooks‐Wilson, Leon F.A.G. Massuger, Lambertus A. Kiemeney, Katja K.H. Aben, Anne M. van Altena, Richard S. Houlston, Ian Tomlinson, Rachel T. Palmieri, Patricia G. Moorman, Joellen M. Schildkraut, Edwin S. Iversen, Catherine Phelan, Robert A. Vierkant, Julie M. Cunningham, Ellen L. Goode, Brooke L. Fridley, Susan Kruger-Kjaer, Jan Blaeker, Estrid Høgdall, Claus Høgdall, Jenny Gross, Beth Y. Karlan, Roberta B. Ness, Robert P. Edwards, Kunle Odunsi, Kirsten B Moyisch, Julie Baker, Francesmary Modugno, Tuomas Heikkinen, Ralf Butzow, Heli Nevanlinna, Arto Leminen, Natalia Bogdanova, Natalia Antonenkova, Thilo Doerk, Peter Hillemanns, Matthias Dürst, Ingo B. Runnebaum, Pamela J. Thompson, Michael E. Carney, Marc T. Goodman, Galina Lurie, Shan Wang‐Gohrke, Rebecca Hein, Jenny Chang‐Claude, Mary Anne Rossing, Kara L. Cushing‐Haugen, Jennifer A. Doherty, Chu Chen, Þórunn Rafnar, Søren Besenbacher, Patrick Sulem, Kari Stefansson, Michael J. Birrer, Kathryn L. Terry, Dena Hernández, Daniel W. Cramer, Ignace Vergote, Frédéric Amant, Diether Lambrechts, Evelyn Despierre, Peter A. Fasching, Matthias W Beckmann, Falk C. Thiel, Arif B. Ekici, Xiaoqing Chen, Sharon E. Johnatty, Penelope M. Webb, Jonathan Beesley, Stephen J. Chanock, Montserrat García‐Closas, Tom Sellers, Douglas F. Easton, Andrew Berchuck, Georgia Chenevix‐Trench, Paul D.P. Pharoah, Simon A. Gayther

Bibliographic record

VenueNature Genetics · 2010
Typearticle
Languageen
FieldMedicine
TopicOvarian cancer diagnosis and treatment
Canadian institutionsSimon Fraser UniversityAlberta Health ServicesBC Cancer AgencyCoalition for Research in Women's Health
FundersNational Cancer InstituteNational Institutes of HealthCancer Research UKWellcome Trust
KeywordsOvarian cancerBiologySingle-nucleotide polymorphismGenome-wide association studyLocus (genetics)Serous fluidEpithelial ovarian cancerMalignancyGeneCandidate geneGenetic associationOncologyCancerInternal medicineGeneticsGenotypeMedicine

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.025
Threshold uncertainty score0.993

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.012
GPT teacher head0.292
Teacher spread0.280 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations257
Published2010
Admission routes1
Has abstractno

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