One‐Pot Oxidative Passerini Reaction of Alcohols Using a Magnetically Recyclable TEMPO under Metal‐ and Halogen‐Free Conditions
Bibliographic record
Abstract
Abstract A novel domino oxidative Passerini three‐component reaction (OP‐3CR) has been successfully developed with either primary or secondary alcohols instead of their corresponding aldehydes or ketones by using a recyclable magnetic core‐shell nanoparticle supported TEMPO (2,2,6,6‐tetramethyl‐piperidin‐1‐oxyl) (MNST, 1). It has been shown that MNST is a highly effective and recyclable catalyst system in the metal‐ and halogen‐free aerobic, oxidative, three‐component Passerini reaction. To the best of our knowledge this method can be considered as the first example of a OP‐3CR of alcohols under metal‐ and halogen‐free reaction conditions. It should be also noted that there has been no precedent example of oxidative OP‐3CR of secondary alcohols to their corresponding α‐acyloxy carboxamides. The catalyst can be magnetically recycled and successfully reused in 14 subsequent reaction cycles with only slight decreases of its catalytic activity.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".