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Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma

2014· article· en· 910 citations· W1985928174 on OpenAlex· 10.1038/nature13121

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian funderA Canadian agency funded it. The work may carry no Canadian affiliation at all.

No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.

Abstract

No abstract. This is not a gap in this database — OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

The record

Venue
Nature
Topic
Melanoma and MAPK Pathways
Field
Biochemistry, Genetics and Molecular Biology
Canadian institutions
Funders
Canadian Institutes of Health Research
Keywords
MelanomaCancer researchVemurafenibV600EMEK inhibitorEpidermal growth factor receptorMAPK/ERK pathwayEGFR inhibitorsSelumetinibBiologyMedicineOncogeneKinaseCancerMutationInternal medicineCell cycleCell biology
Has abstract in OpenAlex
no