Association of Dietary Patterns With Cancer Recurrence and Survival in Patients With Stage III Colon Cancer
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
While dietary factors have been implicated in the risk of developing colon cancer, it is not clear whether diet influences the outcome in patients who have established disease. This question was addressed in a prospective observational study of 1009 patients with stage III colon cancer who enrolled in a randomized trial of adjuvant chemotherapy in 1999–2001. Participants were asked to complete a semiquantitative food frequency questionnaire midway in the course of chemotherapy and again about 6 months after adjuvant therapy ceased. Two major dietary patterns emerged: a prudent pattern with high intakes of fruits and vegetables, poultry, and fish; and a Western pattern with high intakes of meat, fat, refined grains, and deserts. The median follow-up interval was 5.3 years. Recurrent disease developed during follow-up in 324 patients, and 223 of them died with recurrent disease. Another 28 patients died without documented recurrent disease. Higher intake of a Western dietary pattern following diagnosis of colon cancer was associated with significantly worse disease-free survival. Compared with patients in the lowest quintile of the Western pattern, those in the highest quintile had an adjusted hazard ratio (AHR) for disease-free survival of 3.25 (95% confidence interval [CI], 2.04–5.19). The AHR for recurrence-free survival was 2.85 (95% CI, 1.75–4.63). For overall survival, the AHR associated with intake of a Western dietary pattern was 2.32, with a 95% CI of 1.36–3.96. The reduced disease-free survival associated with a Western diet was not significantly altered when adjusted for gender, age, lymph node stage, body mass index, level of physical activity, performance status at baseline, or treatment group. The prudent dietary pattern, in contrast, was not significantly associated with recurrent cancer or cancer mortality. The AHR for disease-free survival, comparing the highest and lowest quintiles of the prudent dietary pattern, was 1.20 (95% CI, 0.83–1.75). There also was no relationship between the prudent pattern and either recurrence-free survival or overall survival. The investigators believe this to be the first study in a potentially cured group of colon cancer survivors to analyze the effects of diet. Further studies hopefully will identify those elements of a Western dietary pattern that are most closely associated with an adverse outcome.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it