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Record W1986230814 · doi:10.1159/000242668

Cell Proliferation in Developing Human Jejunum

2009· article· en· W1986230814 on OpenAlexaff
Pierre Arsenault, Daniel Ménard

Bibliographic record

VenueBiology of the Neonate · 2009
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicDigestive system and related health
Canadian institutionsUniversité de Sherbrooke
Fundersnot available
KeywordsMesenchymeJejunumEpitheliumBiologyCell growthGestationExplant cultureOrgan cultureFetusPathologyAndrologyMesenchymal stem cellCell biologyEndocrinologyMedicinePregnancyIn vitroBiochemistry

Abstract

fetched live from OpenAlex

Cell proliferation of the developing human jejunum was investigated by radioautography using organ culture. The sites of [3H]-thymidine uptake were localized in the epithelium, the mesenchyme and the muscularis externa of fetal human small intestinal explants from 8 to 18 weeks of gestation. Proliferating cells were abundant and scattered throughout the stratified epithelium before the appearance of villi. Many nuclei in the mesenchyme and the muscular layer were labeled. With the villi formation and the simplification of the epithelium, there was a confinement of the proliferating zone in the intervillus areas and developing crypts. The quantitation of proliferating cells showed a labeling index at its highest value between 8 and 10 weeks of gestation decreasing gradually up to 18 weeks of gestation at the epithelial and mesenchymal level. In the muscularis externa, the labeling remained more or less constant between 11 and 18 weeks of gestation. The organ culture of intestinal explants for 5 days did not modify epithelial cell proliferation. The present investigation provides for the first time basic quantitative data regarding cell proliferation in the developing human jejunum.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.001
Threshold uncertainty score0.005

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.011
GPT teacher head0.276
Teacher spread0.264 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations25
Published2009
Admission routes1
Has abstractyes

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