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Record W1986230814 · doi:10.1159/000242668

Cell Proliferation in Developing Human Jejunum

2009· article· en· W1986230814 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueBiology of the Neonate · 2009
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicDigestive system and related health
Canadian institutionsUniversité de Sherbrooke
Fundersnot available
KeywordsMesenchymeJejunumEpitheliumBiologyCell growthGestationExplant cultureOrgan cultureFetusPathologyAndrologyMesenchymal stem cellCell biologyEndocrinologyMedicinePregnancyIn vitroBiochemistry

Abstract

fetched live from OpenAlex

Cell proliferation of the developing human jejunum was investigated by radioautography using organ culture. The sites of [3H]-thymidine uptake were localized in the epithelium, the mesenchyme and the muscularis externa of fetal human small intestinal explants from 8 to 18 weeks of gestation. Proliferating cells were abundant and scattered throughout the stratified epithelium before the appearance of villi. Many nuclei in the mesenchyme and the muscular layer were labeled. With the villi formation and the simplification of the epithelium, there was a confinement of the proliferating zone in the intervillus areas and developing crypts. The quantitation of proliferating cells showed a labeling index at its highest value between 8 and 10 weeks of gestation decreasing gradually up to 18 weeks of gestation at the epithelial and mesenchymal level. In the muscularis externa, the labeling remained more or less constant between 11 and 18 weeks of gestation. The organ culture of intestinal explants for 5 days did not modify epithelial cell proliferation. The present investigation provides for the first time basic quantitative data regarding cell proliferation in the developing human jejunum.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.175
Threshold uncertainty score0.182

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.011
GPT teacher head0.276
Teacher spread0.264 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it