p120 Catenin Reduction and Cytoplasmic Relocalization Leads to Dysregulation of E-Cadherin in Solid Pseudopapillary Tumors of the Pancreas
Bibliographic record
Abstract
Solid pseudopapillary tumors (SPTs) of the pancreas have characteristic morphologic features and show consistent beta-catenin abnormalities and loss of E-cadherin protein. The loss of cell-to-cell adhesion is thought to contribute to frequent cystic degeneration and pseudopapillae formation. p120 regulates E-cadherin and is responsible for its degradation.A tissue microarray of 20 cases and whole sections from another 9 cases of SPT were stained with p120, beta-catenin, and E-cadherin. All 29 cases showed cytoplasmic and nuclear staining for beta-catenin, loss of E-cadherin, and decrease or loss of p120 membrane localization but cytoplasmic staining instead. Loss of membrane p120 staining with relocalization to the cytoplasm was seen in cystic and solid areas of the tumors. This study indicates that p120 expression in SPTs is abnormal and loss of E-cadherin is probably consequent on p120 loss or decrease. Aberrations and other alterations of the E-cadherin gene are unlikely to be responsible for the loss of E-cadherin in SPTs.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".