MétaCan
Menu
Back to cohort
Record W1987015380 · doi:10.1159/000241600

Influence of Corticosteroids on Glycogen Content and Steroid 11-Reductase Activity in Lung and Liver of the Fetal and Newborn Rat

2009· article· en· W1987015380 on OpenAlexaff
Barry T. Smith, Keith Tanswell, D. Minshall, W.N. Bogues, E. Vreeken

Bibliographic record

VenueBiology of the Neonate · 2009
Typearticle
Languageen
FieldMedicine
TopicNeonatal Respiratory Health Research
Canadian institutionsQueen's University
Fundersnot available
KeywordsBetamethasoneEndocrinologyGlycogenInternal medicineCorticosteroidLungFetusGlucocorticoidGestationBiologyMedicinePregnancy

Abstract

fetched live from OpenAlex

Lung and liver glycogen and corticosteroid 11-reductase activity were studied in fetal and neonatal rats. Glycogen content peaked in the lung on day 20 of gestation, while hepatic glycogen content was generally lower and peaked later. Both pre- and postnatally, betamethasone administration resulted in lowered pulmonary and elevated hepatic glycogen. In both lung and liver, corticosteroid 11-reductase activity showed an inverse developmental pattern to glycogen content. Betamethasone elevated pulmonary corticosteroid 11-reductase activity and lowered hepatic activity. In lung and liver, glycogen content and corticosteroid 11-reductase activity are tightly linked during development and following glucocorticoid therapy.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.676
Threshold uncertainty score0.257

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.039
GPT teacher head0.326
Teacher spread0.287 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations16
Published2009
Admission routes1
Has abstractyes

Explore more

Same venueBiology of the NeonateSame topicNeonatal Respiratory Health ResearchFrench-language works237,207