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Record W1987313243 · doi:10.1038/nature14169

Whole genomes redefine the mutational landscape of pancreatic cancer

2015· article· en· W1987313243 on OpenAlexaff
Nicola Waddell, Marina Pajic, Ann‐Marie Patch, David K. Chang, Karin S. Kassahn, Peter J. Bailey, Amber L. Johns, David S. Miller, Kátia Nones, Kelly Quek, Michael C. Quinn, Alan J. Robertson, Muhammad Zaki Hidayatullah Fadlullah, Timothy J. C. Bruxner, Angelika N. Christ, Ivon Harliwong, Senel Idrisoglu, Suzanne Manning, Craig Nourse, Ehsan Nourbakhsh, Shivangi Wani, Peter J. Wilson, Emma Markham, Nicole Cloonan, Matthew J. Anderson, J. Lynn Fink, Oliver Holmes, Stephen H. Kazakoff, Conrad Leonard, Felicity Newell, Barsha Poudel, Sarah Song, Darrin F. Taylor, Nick M. Waddell, Scott Wood, Qinying Xu, Jianmin Wu, Mark Pinese, Mark J. Cowley, Hong C. Lee, Marc D. Jones, Adnan Nagrial, Jeremy L. Humphris, Lorraine A. Chantrill, Venessa Chin, Angela Steinmann, Amanda Mawson, Emily S. Humphrey, Emily K. Colvin, Angela Chou, Christopher J. Scarlett, Andreia V. Pinho, Marc Giry-Laterrière, Ilse Rooman, Jaswinder S. Samra, James G. Kench, Jessica A. Pettitt, Neil D. Merrett, Christopher W. Toon, Krishna Epari, Nam Q. Nguyen, Andrew P. Barbour, Nikolajs Zeps, Nigel B. Jamieson, Janet Graham, Simone P. Niclou, Rolf Bjerkvig, Robert Grützmann, Daniela E. Aust, Ralph H. Hruban, Anirban Maitra, Christine A. Iacobuzio–Donahue, Christopher L. Wolfgang, Richard A. Morgan, Rita T. Lawlor, Vincenzo Corbo, Claudio Bassi, Massimo Falconi, Giuseppe Zamboni, Giampaolo Tortora, Margaret A. Tempero, Anthony J. Gill, James R. Eshleman, Christian Pilarsky, Aldo Scarpa, Elizabeth A. Musgrove, John V. Pearson, Andrew V. Biankin, Sean M. Grimmond

Bibliographic record

VenueNature · 2015
Typearticle
Languageen
FieldMedicine
TopicPancreatic and Hepatic Oncology Research
Canadian institutionsPancreas Centre (Canada)
FundersNational Cancer InstituteMedical Research CouncilQueensland GovernmentNational Institutes of HealthRoyal Australasian College of PhysiciansGastroenterological Society of AustraliaCancer Institute NSWUniversità degli Studi di VeronaUniversity of GlasgowCancer Council NSWNational Health and Medical Research CouncilAcademy of Medical SciencesCancer Research UKAustralian Cancer Research FoundationAustralian GovernmentPetre FoundationWellcome TrustRoyal College of Pathologists of AustralasiaJohns Hopkins UniversityR.T. Hall TrustAmerican Association for Cancer Research
KeywordsCDKN2APancreatic cancerBiologyGenome instabilityCarcinogenesisGenomeCopy-number variationCancer researchCopy number analysisCancerGeneticsARID1AGenePALB2MutationDNA damageGermline mutationDNA

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.004
Threshold uncertainty score0.012

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0010.001
Open science0.0000.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0040.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.033
GPT teacher head0.363
Teacher spread0.329 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2,673
Published2015
Admission routes1
Has abstractno

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