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The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9

2006· article· en· 710 citations· W1987410025 on OpenAlex· 10.1038/ni1297

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian affiliationAn author listed a Canadian institution. This is the only route the usual frame has.

Classifier prediction

metacan-v1-d91a1de5be90

Predictions imitate two machine teachers. Scores are not calibrated prevalence probabilities.

Classifier candidate
Bench or experimentalNot applicable
Classifier consensus
Bench or experimental
Teacher imitation scores

Codex

Bench or experimental0.824
Other design0.011
Observational0.002
Not applicable0.002
Research integrity0.000
Meta-analysis0.000
Theoretical or conceptual0.000
Case report0.000
Scholarly communication0.000
Systematic review0.000
Bibliometrics0.000
Randomized trial0.000
Non-randomized trial0.000
Simulation or modelling0.000
Science and technology studies0.000
Qualitative0.000
Open science0.000
Metaresearch0.000
Meta-epidemiology (narrow)0.000
Meta-epidemiology (broad)0.000

Gemma

Bench or experimental0.675
Not applicable0.060
Observational0.001
Non-randomized trial0.000
Theoretical or conceptual0.000
Research integrity0.000
Randomized trial0.000
Meta-analysis0.000
Qualitative0.000
Case report0.000
Metaresearch0.000
Science and technology studies0.000
Scholarly communication0.000
Systematic review0.000
Simulation or modelling0.000
Meta-epidemiology (broad)0.000
Meta-epidemiology (narrow)0.000
Bibliometrics0.000
Open science0.000

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.003
GPT teacher head0.218
Teacher spread
0.215 how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

Here we have identified 'triple D' (3d), a recessive N-ethyl-N-nitrosourea-induced mutation and phenotype in which no signaling occurs via the intracellular Toll-like receptors 3, 7 and 9 (sensors for double-stranded RNA, single-stranded RNA and unmethylated DNA, respectively). The 3d mutation also prevented cross-presentation and diminished major histocompatibility complex class II presentation of exogenous antigen; it also caused hypersusceptibility to infection by mouse cytomegalovirus and ot…

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