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Record W1987697376 · doi:10.1159/000136937

Electrical and Mechanical Activity of the Isolated Canine Stomach Perfused with Homologous, in vitro, Oxygenated Blood

2008· article· en· W1987697376 on OpenAlexaff
K. Kowalewski, S Zajaç

Bibliographic record

VenuePharmacology · 2008
Typearticle
Languageen
FieldNeuroscience
TopicVagus Nerve Stimulation Research
Canadian institutionsAlberta Medical AssociationUniversity of Alberta
Fundersnot available
KeywordsPerfusionIn vitroStomachStimulationPentagastrinCholinergicCarnivoraFissipediaChemistryPharmacologyBiologyMedicineEndocrinologyInternal medicineBiochemistryGastric acid

Abstract

fetched live from OpenAlex

Electrical and mechanical activity was recorded from six totally isolated canine stomachs perfused with homologous blood oxygenated in vitro. Reactions to electrical vagal stimulation to cholinergic drugs and to pentagastrin were recorded. Electrical control activity, electrical response activity and mechanical response of isolated stomachs, observed in this in vitro system, were identical to those found in canine-isolated stomachs perfused with cross-circulated blood of living animals. It appears that when a living animal is included in the perfusion system of the isolated stomach, drugs used for gastric stimulation are rapidly metabolized and, due to this physiological clearance, repeated injections of stimulants can be given for several hours. Using the in vitro perfusion system, as in this experiment, injected drugs accumulate in the perfusion blood, as no clearance mechanism is available. Partial or total exchange of perfusion blood is therefore recommended. With these reservations, the in vitro system appears to be an easy method for the study of nonstimulated and stimulated electrical and mechanical activity of the totally isolated canine stomach.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.103
Threshold uncertainty score0.341

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.034
GPT teacher head0.306
Teacher spread0.272 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2008
Admission routes1
Has abstractyes

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