The Directed <i>ortho</i> Metalation Reaction – A Point of Departure for New Synthetic Aromatic Chemistry
Bibliographic record
Abstract
This chapter contains sections titled: Introduction The DoM Reaction as a Methodological Tool The N-Cumyl Carboxamide, Sulfonamide, and O-Carbamate DMGs The Lithio Carboxylate and Carboxylate Ester DMGs The Di-tert-Butyl Phosphine Oxide DMG Heteroaromatic Directed ortho Metalation (HetDoM) in Methodological Practice π-Excessive Heteroaromatic Directed ortho Metalation (HetDoM) π-Deficient Heteroaromatic Directed ortho Metalation (HetDoM) The DoM–Transition Metal Catalyzed Aryl–Aryl Cross-Coupling Symbiosis The Suzuki–Miyaura–DoM Link Aryl O-Carbamate and S-Thiocarbamate–Grignard Cross-Coupling Reactions The DoM–Negishi Cross-Coupling Connection DoM–Derived Cross-Coupling Reactions. Synthetic Comparison of Boron, Zinc, and Magnesium Coupling Partners Beyond DoM: The Directed Remote Metalation (DreM) of Biaryl Amides and O-Carbamates – New Methodologies for Condensed Aromatics and Heteroaromatics Heteroatom-Bridged Biaryl DreM. General Anionic Friedel–Crafts Complements for Several Classes of Heterocycles Interfacing DoM with Emerging Synthetic Methods Closing Comments
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.010 | 0.004 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".