Involvement of two related porins, OprD and OpdP, in the uptake of arginine by<i>Pseudomonas aeruginosa</i>
Bibliographic record
Abstract
The OprD family of specific porins in Pseudomonas aeruginosa comprises 19 members, some of which have been demonstrated to facilitate the uptake of specific compounds into the cell. The members of this family share considerable amino acid sequence similarity (46-57%), which is unusual among porin molecules. In this work, we sought to establish whether this sequence conservation was the basis for other shared aspects of this family. The transcriptional profiles of eight relatively well-characterized OprD homologs were assessed in cells grown on a variety of carbon compounds. The expression of these paralogous proteins correlated with their phylogenetic distribution into two subfamilies in that the three members of the OpdK subfamily were induced by their specific (organic acid) substrates while the five members of the amino-acid/peptide-specific OprD subfamily appeared to be constitutively expressed. Functional overlap with respect to arginine transport was observed between two members of the latter subfamily, the basic amino acid-specific porin, OprD, and the glycine-glutamate-specific porin, OpdP. The impact of this apparent functional redundancy on the genetic fitness of P. aeruginosa is discussed.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".