Bibliographic record
Abstract
The nematode Caenorhabditis elegans displays a surprisingly sophisticated behavioral repertoire that includes the utilization of both associative and non-associative forms of learning. Elucidating the molecular basis of learning remains a fundamental, yet daunting, challenge of modern neuroscience. In Pereira and van der Kooy (ref. 2), we described the use of a two input-two output stimuli system to dissociate between associative and non-associative learning and between memory acquisition and retrieval processes. Briefly, one finding indicated that after training with the odorant isoamyl alcohol (IsoA), we could preferentially retrieve either associative or non-associative memory with a choice of either a benzaldehyde (Bnz) or IsoA retrieval stimulus, respectively. Here, we describe how that apparently enigmatic molecular cross wiring of the two forms of memory examined could represent an evolutionary relic of the ancient divergence between non-associative and associative learning. In addition, we extrapolate on the utility and subtleties of using such a system to dissociate and decipher the components of memory in C. elegans.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.004 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".