Cyclosporin A Treatment Is Associated with Increased Serum Immunoglobulin E Levels in a Subgroup of Atopic Dermatitis Patients
Bibliographic record
Abstract
Cyclosporin A is increasingly used in the treatment of severe refractory atopic dermatitis. Although cyclosporin A treatment is highly efficacious and relatively safe, we report four adult atopic dermatitis (AD) patients who deteriorated during long-term cyclosporin A treatment, with clinical signs and symptoms more severe than at the onset of treatment. Interestingly, these patients showed large increases of total serum immunoglobulin E (IgE) levels, paralleled by increasing disease severity and serum levels of thymus and activation-regulated chemokine. This implies that cyclosporin A may induce a shift to Th2, resulting in increased IgE synthesis, in a subpopulation of AD patients. We therefore suggest that in this subpopulation, treatment with anti-B cell or combined anti-B and T-cell treatment may be favorable.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".