Bibliographic record
Abstract
Diclofenac is a well-tolerated, traditional nonsteroidal anti-inflammatory drug that has been shown to be very effective for the treatment of osteoarthritis. Serendipitously, diclofenac has been shown to be relatively selective for cyclooxygenase-2; perhaps due to that fact, it has proven to be well tolerated. Tolerance and utility have been augmented with a variety of formulations, including extended-release tablets, a combination tablet with misoprostol, a suppository preparation and a topically absorbed solution. Sodium diclofenac tablets are available in 25 and 50 mg units, the extended-release tablets are available in 75 and 100 mg units, and the suppositories in 50 and 100 mg units. The usual daily dose ranges from 75 to 150 mg, ingested as two or three divided doses. The drug is a phenylacetic acid derivative. Although it is completely absorbed, only 60% is thought to reach the systemic circulation due to first-pass metabolism. The area under the plasma concentration curve is proportional to the dose in the range of 25–150 mg.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.006 | 0.004 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".